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processing.... Drugs & Diseases > Infectious Diseases Coronavirus Disease 2019 (COVID-19) Updated: Feb 01, 2023 Author: David J Cennimo, MD, FAAP, FACP, FIDSA, AAHIVS; Chief Editor: Michael Stuart Bronze, MD more...
Share Email Print Feedback Close Facebook Twitter LinkedIn WhatsApp webmd.ads2.defineAd(id: 'ads-pos-421-sfp',pos: 421); Sections Coronavirus Disease 2019 (COVID-19) Sections Coronavirus Disease 2019 (COVID-19) Overview Practice Essentials
Background Route of Transmission Epidemiology Prognosis Virology Show All Presentation History
Physical Examination Complications Show All Workup Approach Considerations
Laboratory Studies CT Scanning Chest Radiography Show All Treatment Approach Considerations
Medical Care Prevention Antiviral Agents Immunomodulators and Other Investigational Therapies Investigational Antibody-Directed Therapies Vaccines Antithrombotics Renin Angiotensin System Blockade and COVID-19 Diabetes and COVID-19 Therapies Determined Ineffective QT Prolongation with Potential COVID-19 Pharmacotherapies Investigational Devices Show All Guidelines Guidelines Summary
CDC Evaluating and Testing Persons Under Investigation (PUI) for COVID-19 Clinical Guidelines CDC Sample Collection and Testing Guidelines for COVID-19 Guidance for Hospitals on Containing Spread of COVID-19 American Academy of Pediatrics Guidance on Management of Infants Born to Mothers with COVID-19 NIH Coronavirus Disease 2019 (COVID-19) Treatment Guidelines Infectious Diseases Society of America (IDSA) Management Guidelines Thromboembolism Prevention and Treatment Show All Medication Medication Summary
Vaccines Antiviral Agents Corticosteroids Immunomodulators Monoclonal Antibodies Show All Questions & Answers Media Gallery Tables References Overview Practice Essentials Coronavirus disease 2019 (COVID-19) is defined as illness caused by a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; formerly called 2019-nCoV), which was first identified amid an outbreak of respiratory illness cases in Wuhan City, Hubei Province, China. [1] It was initially reported to the WHO on December 31, 2019. On January 30, 2020, the WHO declared the COVID-19 outbreak a global health emergency. [2, 3] On March 11, 2020, the WHO declared COVID-19 a global pandemic, its first such designation since declaring H1N1 influenza a pandemic in 2009. [4]
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Illness caused by SARS-CoV-2 was termed COVID-19 by the WHO, the acronym derived from "coronavirus disease 2019." The name was chosen to avoid stigmatizing the virus's origins in terms of populations, geography, or animal associations. [5, 6] On February 11, 2020, the Coronavirus Study Group of the International Committee on Taxonomy of Viruses issued a statement announcing an official designation for the novel virus: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). [7]
Remdesivir, an antiviral agent, was the first drug to gain full FDA approval for treatment of hospitalized adults and adolescents with COVID-19 disease in October 2020. [23] Since then, it has gained approval for adults and pediatric patients (aged 28 days and older who weigh at least 3 kg) with positive results of direct SARS-CoV-2 viral testing, who are hospitalized, or not hospitalized and have mild-to-moderate COVID-19, and are at high risk for progression to severe COVID-19, including hospitalization or death. [24]
Admission to the pediatric intensive care unit (PICU) was significantly associated with higher C-reactive protein, procalcitonin, and pro-B type natriuretic peptide levels and platelet counts (P
A cohort study of pregnant patients (n = 64) with severe or critical COVID-19 disease hospitalized at 12 US institutions between March 5, 2020, and April 20, 2020 has been published. At the time of the study, most (81%) received hydroxychloroquine; 7% of those with severe disease and 65% with critical disease received remdesivir. All of those with critical disease received either prophylactic or therapeutic anticoagulation. One case of maternal cardiac arrest occurred, but there were no cases of cardiomyopathy or death. Half (n = 32) delivered during their hospitalization (34% severe group; 85% critical group). Additionally, 88% with critical disease delivered preterm during their disease course, with 16 of 17 (94%) pregnant women giving birth through cesarean delivery. Overall, 15 of 20 (75%) with critical disease delivered preterm. There were no stillbirths or neonatal deaths or cases of vertical transmission. [84]
An in vitro study published in December 2021 indicate that remdesivir, nirmatrelvir, molnupiravir, EIDD-1931, and GS-441524 (oral prodrug of remdesivir) retain their activity against the VOCs Alpha, Beta, Gamma, Delta, and Omicron. [97]
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The social desirability bias is a concern for anyone who uses self-report data. Companies that run internal surveys investigating topics that may cast an employee in a poor light must be aware of how the social desirability bias will affect the validity of their data.
Knowing that people adjust their answers to appear more socially desirable, investigators (such as researchers and clinicians) can try to reframe their questions to be less direct, use formal tests, or anonymize responses.
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